Transcription Factor Enrichment Analysis with ChEA3

Enter a set of Entrez gene symbols below to perform transcription factor enrichment analysis using ChEA3. The result is a subnetwork of connected transcription factors enriched for the query set.
Learn how to prepare differentially expressed gene sets from an RNA-seq gene expression count matrix:  
Learn how to prepare gene sets from a BED file: 
Please acknowledge ChEA3 in your publications using the following reference:

Keenan AB, Torre D, Lachmann A, Leong AK, Wojciechowicz M, Utti V, Jagodnik K, Kropiwnicki E, Wang Z, Ma'ayan A (2019) ChEA3: transcription factor enrichment analysis by orthogonal omics integration. Nucleic Acids Research. doi: 10.1093/nar/gkz446

Please acknowledge ChEA-KG in your publications by citing the following reference:
Anna I. Byrd, John Erol Evangelista, Alexander Lachmann, Ho-Young Chung, Sherry L Jenkins, Avi Ma'ayan. ChEA-KG: Human Transcription Factor Regulatory Network with a Knowledge Graph User Interface.Preprint on bioRxiv (2025). doi:10.1101/2025.08.09.669505.

This website was prepared using the Ma’ayan Lab Knowledge Graph User Interface.
John Erol Evangelista, Andrew D. Lutsky, Anna I. Byrd, Daniel J. B. Clarke, Abinanda Prabhakaran, Sherry L. Jenkins, Avi Ma’ayan. Creating an Interactive Web Interface for Networks Stored in Knowledge Graph Databases. Current Protocols. 16 Sept 2025. https://doi.org/10.1002/cpz1.70200.
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