ChEA-KG
ChEA-KG
Queries:

Transcription Factor Regulatory Subnetworks for GTEx Aging Signatures

Explore upstream transcription factor regulatory subnetworks for tissue-specific aging signatures from the Genotype-Tissue Expression (GTEx) project (https://gtexportal.org/). These regulatory subnetworks are created by submitting up and down aging signatures from the GTEx project to ChEA-KG.
Add/remove nodes:
Add/remove edges:
Regulatory network for genes
up-regulated
with age in the adipose tissue
Please acknowledge ChEA-KG in your publications by citing the following reference:
Anna I. Byrd, John Erol Evangelista, Alexander Lachmann, Ho-Young Chung, Sherry L Jenkins, Avi Ma'ayan. ChEA-KG: Human Transcription Factor Regulatory Network with a Knowledge Graph User Interface.Preprint on bioRxiv (2025). doi:10.1101/2025.08.09.669505.

This website was prepared using the Ma’ayan Lab Knowledge Graph User Interface.
John Erol Evangelista, Andrew D. Lutsky, Anna I. Byrd, Daniel J. B. Clarke, Abinanda Prabhakaran, Sherry L. Jenkins, Avi Ma’ayan. Creating an Interactive Web Interface for Networks Stored in Knowledge Graph Databases. Current Protocols. 16 Sept 2025. https://doi.org/10.1002/cpz1.70200.
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